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Table 1 Characteristics of the studies and general information on the participants

From: Effectiveness of deep brain stimulation on refractory aggression in pediatric patients with autism and severe intellectual disability: meta-analytic review

Author

Year

Country

Design

Included subjects

Pediatric patients

ASD

Severity ASD

ID

Severity ID

Age, ME, Rank

Sex

Benedetti-Isaac

2015

Colombia

RCS

5

3

1

Severe

3

Severe

2PTE:16; 1PTE:19 (ME:17; R:16–19)

2 M/1F

Benedetti-Isaac

2021

Colombia

RCS

19

19

0

-

19

Severe

(ME: 18,4; R: 14–20)

N/A

Benedetti-Isaac

2023a

Colombia

RCS

5

5

5

Severe

0

-

(ME: 15,2; R: 12–17)

4 M/1F

Benedetti-Isaac

2023b

Colombia

RCS

12

12

0

-

12

Severe

(ME: 15,34; R: 1,80)

N/A

Escobar-Vidarte

2022

Colombia

CR

11

8

1

N/A

8

2Mod/6Sev

(ME: 14,75; R: 10–21)

7 M/1F

Franzini

2013

Italy

RCS

7

2

0

-

2

Severe

(ME: 20,5; R: 20–21)

N/A

Giordano

2016

Italy

CR

1

1

0

-

1

Moderate

21 years

M

Harat

2021

Poland

RCS

6

2

1

Severe

1

Moderate

(ME: 17,5; R:16)

PTE1: 16; PTE2: 19

N/A

Heiden

2022

Germany

RCS

10

1

1

Severe

0

-

13 years

M

Kakko

2019

Finland

CR

1

1

1

N/A

1

Moderate

19 years

M

López-Ríos

2022

Colombia

CR

1

1

1

N/A

1

Severe

16 years

F

Maley

2010

USA

CR

1

1

0

-

1

Moderate

19 years

F

Micieli

2017

Colombia

RCS

4

4

0

-

4

3Mod/1Sev

ME:15,25; R:10–19

1F/3 M

Park

2017

Korea

CR

1

1

1

N/A

1

N/A

14

M

Stocco

2014

USA

CR

2

2

2

Severe

2

Severe

(ME: 17,66; R: 17–19)

PTE1: 19; PTE2: 17

1 M/1F

Sturm

2012

Germany

CR

1

1

1

Severe

1

Severe

13 years

M

Torres

2013

Spain

RCS

6

1

1

Severe

1

Severe

17 years

M

Torres

2020

Spain

RCS

7

  1. RCS Retrospective case series, CR Case report, ASD Autism Spectrum Disorders, ID Intellectual Disability, PTE Patient, ME Media, R Rank, M Male, F Female, N/A Not available