Table 5 Complications

Benedetti‐Isaac et al., 2015 [25]

2/3

PTE 1: Died due to causes other than deep brain stimulation after the last follow-up. PTE 3: After two months, aggressiveness returned to baseline.

Benedetti‐Isaac et al., 2021 [24]

1/19

1 patient with basal ganglia hemorrhage

Benedetti‐Isaac, et al., 2023a [22]

-

None

Benedetti‐Isaac, et al., 2023b [23]

-

None

Escobar Vidarte et al., 2022 [32]

5/8

During follow-up, patients 1, 2, and 5 experienced GPI issues and increased aggression, which improved after generator replacement and resumption of hypothalamic stimulation. PTE 10: Device replacement required due to surgical site infection. PTE 11: As the stimulation parameters were increased, conjugate lateral gaze deviation occurred. The family requested explantation.

Franzini et al., 2013 [25]

-

None

Giordano et al., 2016 [5]

-

None

Harat et al., 2021 [2]

2/2

PTE 1: He received the first DBS (Naac) with some improvement, he underwent a second intervention in the posteromedial thalamus, he suffered infection, and the device was removed. PTE 2: Malfunction of the Impulse Pulse Generator (IPG).

Heiden et al., 2022 [39]

1/1

No clinical follow-up occurred due to missed follow-up appointments.

Kakko et al., 2019 [35]

-

None

López Ríos et al., 2022 [33]

1/1

Parameters were adjusted several times to improve treatment efficacy because of persistent insomnia and agitation and to minimize the mild side effects associated with higher-voltage stimulation.

Maley et al., 2010 [40]

1/1

Several stimulation adjustments were necessary because of the aggression and other pathologies observed until 12 months of age; after changing the parameters, aggressiveness decreased.

Micieli et al., 2017 [34]

2/4

PTE 1: Battery site infection. PTE 2: Transient dystonia of the left upper extremity improves with changes in stimulation.

Park et al., 2017 [36]

-

None

Stocco, et al., 2014 [38]

1/2

PTE 2: stereotypes back to their original condition

Sturm et al., 2012 [30]

1/1

The battery discharged in the 10th month, leading to the return of aggression. Aggressiveness diminished after battery change.

Torres et al., 2013, 2020 [6, 41]

1/1

2013: None

2020: Increase in blood pressure, heart rate, and headache.