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Table 2 Morbidites and survival in EPIs with gestation age < 28w receiving complete care

From: A real-world study on the treatment of extremely preterm infants: a multi-center study in southwest area of Fujian Province in China

 

N = 368

22–22+ 6w

n = 0

23–23+ 6w

n = 7

24–24+ 6w

n = 22

25–25+ 6

n = 47

26–26+ 6w

n = 98

27–27+ 6w

n = 194

Z/χ2

P

RDS

0

46(12.5)

-

2(28.6)

4(18.2)

4(8.5)

15(15.3)

21(10.8)

25.796

< 0.001

1

204(55.4)

-

1(14.3)

9(40.9)

18(38.3)

49(50)

127(65.5)

  

2

118(32.1)

-

4(57.1)

9(40.9)

25(53.2)

34(34.7)

46(23.7)

  

II to III level BPD

148(40.2)

-

2(28.6)

10(45.5)

24(51.1)

47(48)

65(33.5)

9/030

0.056

VAP

22(6.0)

-

1(14.3)

1(4.5)

4(8.5)

7(7.1)

9(4.6)

3.265

0.443

hsPDA

132(35.9)

-

0

9(40.9)

24(51.1)

35(35.7)

64(33)

9.500

0.045

ROP

255(69.8)

-

1(14.3)

11(50)

39(83)

76(77.6)

130(67)

20.380

< 0.001

ROP requiring intervention

41(13.1)

-

1(14.3)

4(18.2)

8(17.0)

16(16.3)

13(6.7)

10.209

0.027

NEC ≥ 2

29(7.9)

-

0

1(4.5)

4(8.5)

12(12.2)

12(6.2)

3.410

0.445

BI

84(22.8)

-

2(28.6)

7(31.8)

16(34)

21(21.4)

38(19.6)

5.418

0.247

IVH ≥ 3

40(10.9)

-

2(28.6)

6(27.3)

6(12.8)

10(10.2)

16(8.2)

9.355

0.040

PVL

63(17.1)

-

1(14.3)

3(13.6)

15(31.9)

17(17.3)

29(14.9)

3.710

0.576

MBDP

21(5.7)

-

1(14.3)

1(4.5)

5(10.6)

2(2)

12(6.2)

6.468

0.126

PNAC

68(18.5)

-

1(14.3)

1(4.5)

4(8.5)

21(21.4)

41(21.1)

7.350

0.096

EOS

34(9.2)

-

2(28.6)

2(9.1)

5(10.6)

8(8.2)

17(8.8)

3.396

0.439

LOS

52(14.1)

-

1(14.3)

2(9.1)

4(8.5)

18(18.4)

27(13.9)

2.949

0.542

Morbidities of major serious disease

221(60.1)

-

3(42.9)

16(72.7)

32(68.1)

64(65.3)

106(54.6)

11.743

0.008

All-cause mortality

1691/2004(84.4)

189/189(100)

223/223(100)

394/407(96.8)

389/428(90.9)

270/357(75.6)

226/400(56.5)

394.360

< 0.001

Survival rate of EPIs transfered to NICU

313/469(66.7)

0

0

13/38(34.2)

39/75(52)

87/124(70.2)

174/216(80.6)

75.708

< 0.001

Survival rate of EPIs received complete care

313(85.1)

-

0

13(59.1)

39(83.0)

87(88.8)

174(89.7)

38.718

< 0.001

Survival rate of EPIs without major serious diseases

116(31.5)

-

0

2(9.1)

9(19.1)

27(27.6)

78(40.2)

19.142

0.001

  1. Data are presented as median(inter quartile range) or n (%); χ2 is the statistic value of the Pearson’s chi-square test or continuity correction of Pearson’s chi-square test, and Z is the statistic value of the Kruskal-Wallis rank-sum test.
  2. Note: EPIs: extremely preterm infants; RDS: neonatal respiratory distress syndrome, 2 refers to the grade 3–4 RDS; EOS: early onset sepsis; LOS later onset sepsis; NEC: necrotizing enterocolitis; hsPDA: hemodynamically significant patent ductus arteriosus; BPD: bronchopulmonary dysplasia; BI: brain injury. ROP: retinopathy of prematurity; MBDP: metabolic bone disease of prematurity; PNAC: parenteral nutrition-associated cholestasis.