Association of SLCO1B1 genetic variants with neonatal hyperbilirubinemia: a consolidated analysis of 36 studies

Talebi, Hanieh; Dastgheib, Seyed Alireza; Vafapour, Maryam; Bahrami, Reza; Shahbazi, Amirhossein; Shams, Seyedeh Elham; Danaei, Mahsa; Rashnavadi, Heewa; Yeganegi, Maryam; Pourkazemi, Melina; Shiri, Amirmasoud; Aghasipour, Maryam; Neamatzadeh, Hossein

doi:10.1186/s12887-025-05493-z

BMC Pediatrics

Table 1 Characteristics of studies included in this meta-analysis

From: Association of SLCO1B1 genetic variants with neonatal hyperbilirubinemia: a consolidated analysis of 36 studies

First author/year	Country (ethnicity)	Genotyping methods	Case/Control	Cases					Controls					MAFs	HWE	NOS
First author/year	Country (ethnicity)	Genotyping methods	Case/Control	Genotypes			Allele		Genotypes			Allele
rs2306283				GG	GA	AA	G	A	GG	GA	AA	G	A
Huang 2004	Taiwan(Asian)	PCR-RFLP	58/75	31	20	7	82	34	53	16	6	122	28	0.187	0.010	6
Tian 2007	China(Asian)	PCR-RFLP	96/101	56	29	11	141	51	75	21	5	171	31	0.153	0.044	7
Wong 2009	Malaysia(Asian)	HRM	65/110	38	19	8	95	35	55	47	8	157	63	0.286	0.634	5
Prachukthum 2009	Thailand(Asian)	PCR-RFLP	91/86	59	28	4	146	36	47	36	3	130	42	0.270	0.799	8
Watchko 2009	USA(Caucasian)	PCR-RFLP	153/298	118	33	2	269	37	228	65	5	521	75	0.126	0.882	7
Zhang 2010	China(Asian)	PCR-RFLP	220/200	127	75	18	329	111	102	77	21	281	119	0.298	0.264	8
Buyukkale 2011	Turkey(Caucasian)	PCR-RFLP	102/53	30	56	16	116	88	17	24	12	58	48	0.453	0.530	6
Jiang 2012	China(Asian)	Sequencing	163/63	95	52	16	242	84	53	8	2	114	12	0.095	0.036	5
de Azevedo 2012	Brazil(Mixed)	TaqMan	157/237	42	78	37	162	152	58	123	56	239	235	0.496	0.558	7
Liu 2013	China(Asian)	PCR-RFLP	183/192	107	59	17	273	93	139	43	10	321	63	0.164	0.011	6
D’Silva 2014	India(Asian)	PCR-RFLP	126/181	25	73	28	123	129	15	80	86	110	252	0.696	0.547	7
Yang 2015	China(Asian)	HRM	129/108	71	41	17	183	75	66	35	7	167	49	0.227	0.428	8
Lu 2015	China(Asian)	PCR-RFLP	121/87	73	39	9	185	57	56	25	6	137	37	0.213	0.185	6
Weng 2016	Taiwan(Asian)	PCR-RFLP	100/344	72	28	0	172	28	234	110	0	578	110	0.160	≤ 0.001	5
Zhou 2018	China(Asian)	Sequencing	286/250	159	112	15	430	142	146	84	20	376	124	0.248	0.116	9
Qizhi 2018	China(Asian)	Sequencing	279/178	177	81	21	435	123	109	61	8	279	77	0.216	0.884	8
Amandito 2019	Indonesia(Asian)	PCR-RFLP	41/47	26	12	3	64	18	34	11	2	79	15	0.160	0.382	5
Atasilp 2022	Thailand(Asian)	TaqMan	67/70	45	21	1	111	23	39	27	4	105	35	0.250	0.811	6
Boskabadi 2022	Iran(Asian)	PCR-RFLP	100/100	8	55	37	71	129	12	56	32	80	120	0.600	0.095	7
Yin 2022	China(Asian)	MLPA-NGS	65/52	28	33	4	89	41	27	19	6	73	31	0.298	0.360	8

rs4149056				TT	TC	CC	T	C	TT	TC	CC	T	C
Huang 2004	Taiwan(Asian)	PCR-RFLP	42/73	31	9	2	71	13	53	19	1	125	21	0.144	0.627	6
Wong 2009	Malaysia(Asian)	HRM	65/110	47	18	0	112	18	81	29	0	191	29	0.132	0.111	5
Watchko 2009	USA(Caucasian)	PCR-RFLP	153/298	58	69	26	185	121	135	117	46	387	209	0.351	0.017	7
Zhang 2010	China(Asian)	PCR-RFLP	220/200	185	34	1	404	36	147	50	3	344	56	0.140	0.588	8
de Azevedo 2012	Brazil(Mixed)	TaqMan	157/237	122	34	1	278	36	179	55	3	413	61	0.129	0.592	6
Liu 2013	China(Asian)	PCR-RFLP	183/192	137	35	11	309	57	141	42	9	324	60	0.156	0.018	7
D’Silva 2014	India(Asian)	PCR-RFLP	126/181	95	29	2	219	33	178	3	0	359	3	0.008	0.910	8
Yang 2015	China(Asian)	HRM	129/107	98	29	2	225	33	76	23	8	175	39	0.182	0.003	6
Lu 2015	China(Asian)	PCR-RFLP	121/87	91	30	0	212	30	63	23	1	149	25	0.144	0.487	9
Zhou 2018	China(Asian)	Sequencing	286/250	230	34	22	494	78	211	26	13	448	52	0.104	≤ 0.001	8
Qizhi 2018	China(Asian)	Sequencing	279/178	227	51	1	505	53	152	25	1	329	27	0.076	0.979	7
Li 2019	China(Asian)	Sequencing	447/544	285	106	56	676	218	398	140	6	936	152	0.140	0.099	8
Atasilp 2022	Thailand(Asian)	TaqMan	67/70	57	9	1	123	11	48	20	2	116	24	0.171	0.961	5
Boskabadi 2022	Iran(Asian)	PCR-RFLP	100/100	80	16	4	176	24	75	24	1	174	26	0.130	0.541	6
Yin 2022	China(Asian)	MLPA-NGS	65/52	48	17	0	113	17	41	11	0	93	11	0.106	0.393	9
Fan 2023	China(Asian)	PCR	144/50	118	25	1	261	27	41	9	0	91	9	0.090	0.484	7

Abbreviations: PCR-RFLP - Restriction Fragment Length Polymorphism; HRM - High-Resolution Melting; MLPA-NGS - Multiplex Ligation-dependent Probe Amplification Next Generation Sequencing; HWE - Hardy-Weinberg Equilibrium; MAF - Minor Allele Frequency; NOS - Newcastle-Ottawa Scale

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