Pulmonary function testing in pediatric allogeneic stem cell transplant recipients to monitor for Bronchiolitis obliterans syndrome: a systematic review

Table 4 Evidence profile of pre-transplant PFT data (PICO 1)

Quality assessment							No. of patients	Result	Quality	Importance
No. of studies	Design	Risk of bias	Inconsistency	Indirectness	Imprecision	Other	No. of patients	Result	Quality	Importance
Diagnostic yield: FEV1
16	Observational	No serious risk of bias	Serious*	None	None	Possibility of very large percentage of abnormal tests	2200	All with normal FEV1 in 3 studies Range of prevalence of abnormal: 4–41%. Severe abnormalities: 0–13%	Moderate	Important
Diagnostic yield: FEV1/FVC
13	Observational	No serious risk of bias	Serious*	None	None	Possibility of very large percentage of abnormal tests	909	All with normal FEV1/FVC in 2 studies Range of abnormalities: 5–20%	Moderate	Important
Diagnostic yield: FEF25-75%
4	Observational	No serious risk of bias	Serious*	None	None	Possibility of very large percentage of abnormal tests	655	Range of abnormalities: 3–28%	Moderate	Important
Diagnostic yield: FVC
10	Observational	No serious risk of bias	Serious*	None	None	Possibility of very large percentage of abnormal tests	1543	All with normal FVC in 2 studies Range of abnormalities: 10–31%	Moderate	Important
Diagnostic yield: DLCO
10	Observational	No serious risk of bias	Serious*	None	None	Possibility of very large percentage of abnormal tests	914	All with normal DLCO in 1 study. Range of abnormalities: 3-100%	Moderate	Important

ISSN: 1471-2431