Fig. 1
From: Butyrate inhibits histone deacetylase 2 expression to alleviate liver fibrosis in biliary atresia
The Effect of HDAC2 on LX-2 Activation. (A) IHC results of HDAC2 protein in liver tissues from disease control group (DC), and mild and severe liver fibrosis in BA. (B) Related protein expression after ITSA activation of LX-2 cells. (C) qPCR analysis of HDAC2 mRNA abundance following siRNA-mediated knockdown of HDAC2. (D-E) LX-2 activation after ITSA intervention in HDAC2 knockdown cells. WB and qPCR analysis of mRNA abundance and protein expression of LX-2 activation markers. DC, Disease Control; Ctrl, Control Group; ITSA, ITSA intervention in LX-2 cells; ITSA + BU, BU intervention in LX-2 cells activated by ITSA; con, blank control group; siNC, siRNA non-targeting control group; siHDAC2, siHDAC2, LX-2 Knockdown of HDAC2 by siRNA