From: Impact of inflammation on anemia in children: a cross-sectional study
Variable | Anemia (n = 58) | No anemia (n = 54) | p-value | |
---|---|---|---|---|
General characteristics | ||||
Sex | Male | 33 (56.9) | 29 (53.7) | 0.8491 |
Age | Months | 29.2 ± 7.5 | 28.0 ± 8.4 | 0.9292 |
Maternal education | < 8 years | 47 (81.0) | 44 (81.5) | 0.5791 |
Gestational age | Preterm | 3 (5.2) | 5 (9.3) | 0.1102 |
Birth weight | grams | 3366 ± 548 | 3257 ± 416 | 0.2442 |
Type of delivery | C-section | 20 (34.5) | 15 (27.8) | 0.5711 |
Dietary habits | ||||
Current breastfeeding | Yes | 9 (15.5) | 6 (11.1) | 0.5841 |
Current infant formula | Yes | 27 (46.6) | 30 (55.6) | 0.2831 |
Current cow's milk | Yes | 36 (62.1) | 35 (64.8) | 0.8451 |
Time Exclusive breastfeeding | Months | 4.0 (2.2; 5.7) | 4.5 (3.0; 6.0) | 0.3683 |
Time Total breastfeeding | Months | 4.0 (2.2; 6.7) | 9.0 (3.0; 12.0) | 0.8433 |
Starting age Infant formula | Months | 3.5 (2.5; 5.5) | 6.5 (2.2; 8.0) | 0.3613 |
Age of onset of cow's milk | Months | 12.0 (6.5; 12.0) | 12.0 (8.0; 12.0) | 0.4673 |
Use of Iron Supplements | Yes | 45 (77.6) | 44 (81.5) | 0.6471 |
Health follow-up, socioeconomic status | ||||
Follow-up with a pediatrician | Yes | 48 (82.8) | 47 (87.0) | 0.5371 |
Family Health Strategy | Yes | 39 (67.2) | 41 (75.9) | 0.4031 |
Income Transfer Program | Yes | 15 (25.9) | 10 (18.5) | 0.3741 |
Family economic situation | > B2 | 36 (63.2) | 24 (45.3) | 0.0841 |
Food and Nutrition Insecurity | No | 27 (47.4) | 26 (49.2) | 0.8311 |
Anthropometric indicators | ||||
Body Mass Index/Age | Z score | 0.33 ± 1.24 | 0.79 ± 1.12 | 0.0231 |
Height/Age | Z score | −1.34 ± 1.08 | −0.94 ± 1.28 | 0.0441 |
Dietary pattern (0–23 months) | ||||
Minimal food diversity | Yes | 11 (61.1) | 17 (81.0) | 0.2851 |
Minimum meal frequency | Yes | 17 (94.4) | 18 (85.7) | 0.6091 |
Frequency of milk consumption | Yes | 9 (50.0) | 17 (81.0) | 0.0871 |
Minimum acceptable diet | Yes | 17 (94.4) | 18 (85.7) | 0.6091 |
Egg and/or meat consumption | Yes | 14 (77.8) | 17 (81.0) | 0.5881 |
Consumption of sweet drinks | Yes | 9 (50.0) | 10 (47.6) | 0.5681 |
Consumption of unhealthy foods | Yes | 11 (61.1) | 11 (52.4) | 0.5771 |
No vegetable consumption | No | 17 (94.4) | 18 (85.7) | 0.6091 |
Markers of inflammation | ||||
hsCRP | mg/L | 2.39 (0.68; 14.5) | 1.25 (0.20; 3.41) | 0.0083 |
Alpha-1 Acid Glycoprotein | g/L | 1.36 ± 0.40 | 1.23 ± 0.43 | 0.0922 |
Iron profile markers and anemia | ||||
Hemoglobin | g/dL | 10.4 ± 0.64 | 11.7 ± 0.57 | < 0.0012 |
Red blood cells | mm3 | 4.23 ± 0.34 | 4.60 ± 0.27 | < 0.0012 |
MCV | fL | 79.2 ± 4.8 | 80.6 ± 3.4 | 0.1052 |
MCHC | g/dL | 31.1 ± 0.86 | 31.8 ± 0.87 | < 0.0012 |
Hematocrit | % | 33.4 ± 1.9 | 37.1 ± 1.9 | < 0.0012 |
RDW | % | 14.7 ± 1.37 | 13.8 ± 0.97 | < 0.0012 |
Ferritin | mg/dL | 44.9 ± 26.3 | 40.9 ± 23.0 | 0.4002 |
Serum iron | μg/dL | 51.1 ± 28.6 | 60.4 ± 30.2 | 0.0982 |
Transferrin saturation index | % | 14.3 ± 7.3 | 15.8 ± 8.1 | 0.1102 |
Hepcidin | ng/mL | 0.79 ± 0.62 | 0.72 ± 0.56 | 0.4952 |
Soluble transferrin receptor | mg/L | 1.35 ± 0.82 | 1.10 ± 0.61 | 0.0672 |