Clinical characteristics, and outcomes of severe neonatal thrombocytopenia: a retrospective cohort study in China

BMC Pediatrics

Table 2 Etiologies in different subgroups categorized by onset time of thrombocytopenia and platelet nadir

Diagnosis	Summary (n = 194)	Onset of thrombocytopenia					Platelet nadir(×10⁹/L)
	Summary (n = 194)	≤ 72 h (n = 125)	> 72 h (n = 69)				< 30 (n = 112)		30–50 (n = 82)
Early onset sepsis	43 (22.2)	30 (24.0)		13 (18.8)	0.408	25 (22.3)		18 (22.0)		0.951
Late onset sepsis	30 (15.5)	12 (9.6)		18 (26.1)	0.003	24 (21.4)		6 (7.3)		0.007
CMV infection	13 (6.7)	9 (7.2)		4 (5.8)	0.941	7 (6.3)		6 (7.3)		0.769
Asphyxia	19 (9.8)	17 (13.6)		2 (2.9)	0.016	10 (8.9)		9 (11.0)		0.636
NEC	17 (8.8)	3 (2.4)		14 (20.3)	0.000	11 (9.8)		6 (7.3)		0.542
Post-surgery	2 (1.0)	2 (1.6)		0 (0)	0.539	0 (0)		2 (2.4)		0.346
Hemolytic disease	6 (3.1)	5 (4.0)		1 (1.4)	0.425	1 (0.9)		5 (6.1)		0.099
Genetic	28 (14.4)	21 (16.8)		7 (10.1)	0.207	21 (18.8)		7 (8.5)		0.046
Chromosomal anomalies	3 (1.5)	2 (1.6)		1 (1.4)	1.000	1 (0.9)		2 (2.4)		0.785
Metabolic disorders	9 (4.6)	4 (3.2)		5 (7.2)	0.354	4 (3.1)		5 (6.1)		0.631
KMP	8 (4.1)	6 (4.8)		2 (2.9)	0.714	3 (2.7)		5 (6.1)		0.414
NAT	12 (6.2)	10 (8.0)		2 (2.9)	0.219	4 (3.6)		8 (9.8)		0.077
Idiopathic	4 (2.1)	4 (3.2)		0 (0)	0.299	1 (0.9)		3 (3.7)		0.408

CMV cytomegalovirus, NEC necrotizing enterocolitis, KMP Kasabach-Merritt phenomenon, NAT neonatal alloimmune thrombocytopenia.

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