Fig. 1

Comparison of FHSDS – THSDS among subgroups. A: FHSDS – THSDS by subgroup. SW-male (n = 1): −4.84, SW-female (n = 3): −2.01 (−2.69 to − 0.48), SV-male (n = 2): −2.82 (−4.03 to −1.61), SV-female (n = 9): −0.79 (-2.43 to −0.80), NC-female (n = 4): −0.40(−0.70 to −1.39). No significant difference in overall distribution among subgroups (P = 0.062) B: Classic vs. Non-classic 21OHD. Classic 21OHD(n = 15): −1.48 ± 1.54; Non-classic 21OHD (n = 4): −0.03 ± 0.96. No statistically significant difference (P = 0.094). C: SW phenotype vs. SV phenotype. SW phenotype(n = 4): −2.50 ± 1.81; SV phenotype (n = 11): −1.11 ± 1.34, No statistically significant difference (P = 0.216). D: Male vs. Female Classic 21OHD. Males (n = 3): −3.49 ± 1.68;Females (n = 12): −0.98 ± 1.07. FHSDS – THSDS was significantly lower in males than in females (P = 0.006)