Gene proteins, growth factors/their receptors in the wall of chronic calculous cholecystitis-affected gallbladder children

Table 6 Notable Spearman’s rank correlations between proteins and growth factors/their receptors in patients’ tissues

Strength of correlation	Growth factor/protein	Growth factor/protein	R	p value
Positive correlation
Very strong (0.80-1.000)	IHH E	SHH E	0.933	< 0.001
	IGF1R BV	IGF1R E	0.975	< 0.001
	IGF1R E	IHH E	0.958	< 0.001
	IGF1R E	IHH BV	0.948	< 0.001
	IHH BV	IHH E	0.937	< 0.001
	IHH SM	SHH E	0.917	< 0.001
	IGF1R BV	IHH BV	0.916	< 0.001
	IGF1R BV	IHH E	0.906	< 0.001
	IGF1R SM	IGF1R BV	0.898	< 0.001
	IHH BV	SHH E	0.890	< 0.001
	IHH SM	IHH BV	0.874	< 0.001
	IGF1R E	SHH E	0.862	0.001
	IHH SM	IHH E	0.855	0.001
	IGF1R SM	IGF1R E	0.848	0.001
	IGF1R BV	IHH SM	0.845	0.001
	IGF1R BV	SHH E	0.842	0.001
	IGF1R E	IHH SM	0.839	0.001
	IHH CT	SHH CT	0.818	0.002
	IHH CT	SHH E	0.816	0.002
	IHH CT	IHH E	0.800	0.003
	IGF1R SM	IHH BV	0.800	0.003
Strong (0.60-0.799)	IHH SM	IHH CT	0.770	0.006
	IGF1R SM	IHH E	0.770	0.006
	IGF1R BV	IHH CT	0.741	0.009
	IGF1R E	IHH CT	0.728	0.011
	IGF1R SM	SHH E	0.718	0.013
	IGF1R SM	IHH CT	0.702	0.016
	SHH CT	SHH E	0.700	0.016
	IGF1R SM	IHH SM	0.682	0.021
	IHH SM	SHH CT	0.661	0.027
	IHH BV	IHH CT	0.659	0.028
	IHH E	SHH CT	0.611	0.046
	IGF1R BV	SHH CT	0.607	0.048
Negative correlation
Very strong − (0.80-1.000)	HOXB3 SM	SHH CT	-0.879	< 0.001
	HOXB3 SM	IHH CT	-0.882	< 0.001
	HOXB3 SM	SHH E	-0.830	0.002
Strong − (0.60-0.799)	HOXB3 SM	IHH E	-0.798	0.003
	HOXB3 SM	IHH SM	-0.781	0.005
	HOXB3 SM	IGF1R BV	-0.716	0.013
	HOXB3 SM	IGF1R E	-0.705	0.015
	HOXB3 SM	IHH BV	-0.677	0.022

Abbreviations: SHH−Sonic hedgehog; IHH−Indian hedgehog; IGF1R−insulin-like growth factor 1 receptor; HOXB3−homeobox B3; E−epithelium; CT−connective tissue; BV−blood vessels; SM−smooth myocytes; R−Spearman’s rank correlation coefficient

ISSN: 1471-2431