Evaluation of timed dexamethasone eye drops to prevent proliferative retinopathy of prematurity: a study protocol for a randomized intervention, multi-centre, double-blinded trial (DROPROP)

Table 1 Administration schedule for eye drops according to ROP severity in affected eye/eyes

	Number of drops per day
ROP stage 1–2 without plus disease in zone I	1 drop every other day
ROP stage 2 without plus disease in posterior Zone II	1 drop every other day
ROP stage 3 without plus disease in zone II, with or without notch in zone 1	1 drop daily
Type 1 ROP* fulfilling treatment criteria	If anti-VEGF injection is planned, eye drops should be immediately withdrawn
ROP treatment and post treatment	Routines at the clinic

Abbreviations: ROP Retinopathy of prematurity, VEGF Vascular endothelial growth factor
*Any stage of ROP in zone I, with plus disease; ROP stage 3 in zone I, without plus disease or ROP stage 2 or 3 in zone II, with plus disease

ISSN: 1471-2431