Fig. 1

Ocular manifestations caused by RB1 gene mutation. (A) Initial diagnosis of a stable tumor in a child with RB. (B) B-scan ultrasonography shows a high-density shadow adjacent to the posterior wall of the eyeball. (C) Four months later, a new tumor pattern appeared in the infratemporal portion of the primary lesion (red arrow). (D) OCT shows the retinal interlayer status corresponding to C’s new tumor mass, with unclear boundaries and medium-low reflectivity