Table 2 Clinical profiles of APS2 with concurrent type 1 diabetes mellitus, myasthenia Gravis and autoimmune thyroid disease: insights from comparison with pediatric APS2 cases
From: Autoimmune polyendocrine syndrome type 2 in children: a case report and literature review
Case Number | Gender | Age at Diagnosis | First Diagnosed Disease | Age at onset | Type of MG | Type of T1D | Type of Thyroid Disease | ||
|---|---|---|---|---|---|---|---|---|---|
T1DM | MG | AITD | |||||||
1[22] | F | 8 | Addison’s disease | NA | NA | 11 | NA | NA | AITD |
2[23] | M | 1 | MG | NA | 1 | 1 | Generalized type | NA | AITD |
3[24] | M | 11 | Addison’s disease | NA | NA | 11 | NA | NA | HT |
4[25] | M | 12 | T1D + Thyroid disease | 12 | NA | 12 | NA | Acute onset | GD |
5[26] | F | 9 | T1D | 9 | 19 | 11 | Ocular type | Acute onset | GD |
6[27] | F | 6 | MG | 8 | 6 | 9 | Ocular type | Acute onset | GD |
7[28] | F | 32 | MG | 21 | 32 | 30 | Generalized type | Acute onset | GD |
8[29] | M | 30 | MG | 37 | 31 | 30 | Ocular type | Acute onset | GD |
9[29] | M | 27 | MG | 32 | 27 | 33 | Ocular type | Slowly progressive type | GD |
10[29] | F | 27 | MG + Thyroid disease | 35 | 27 | 27 | Ocular type | Slowly progressive type | GD |
11[29] | F | 19 | T1D + Thyroid disease | 19 | 29 | 19 | Ocular type | Acute onset | GD |
12[29] | M | 37 | MG + Thyroid disease | 43 | 37 | 37 | Ocular type + Upper limb involvement | Slowly progressive type | GD |
13[29] | F | 10 | MG | 15 | 10 | 35 | Ocular type | Acute onset | GD |
14[30] | F | 5 | MG | 40 | 5 | 40 | Ocular type | Acute onset | HT |
15[29] | M | 59 | T1D | 59 | 64 | NA | Ocular type + dysphagia | Acute onset | HT |
16[31] | M | 20 | T1D | 20 | 52 | 52 | Ocular type | Acute onset | AITD |
17[32] | F | 51 | Thyroid disease | 47 | 48 | 47 | Generalized type | Acute onset | HT |
18[33] | M | 37 | T1D | NA | 37 | 37 | Ocular type | NA | AITD |
present case | F | 3 | Thyroid disease | 3 | 4 | 3 | Ocular type | Acute onset | HT |