Table 2 Gene profile of nonsyndromic obesity in children and adolescents
No | Gene | Disease | OMIM | Inheritance | Case(n = 32) |
|---|---|---|---|---|---|
1 | UCP3 | Severe obesity and type 2 diabetes | 601,665 | AD, AR, Mu | 6(19%) |
2 | MC4R | Obesity(BMIQ20) | 618,406 | AD, AR | 4(13%) |
3 | PCSK1 | {Obesity, BMIQ12} | 612,362 | 3(9%) | |
4 | SEMA3D | ?Obesity | 3(9%) | ||
5 | NRP1 | ?Obesity(-; -) | 2(6%) | ||
6 | SEMA3B | ?Obesity(-;-) | 2(6%) | ||
7 | NROB2 | Obesity, mild, early-onset | 601,665 | AD, AR, Mu | 2(6%) |
8 | DYRK1B | Abdominal obesity-metabolic syndrome 3 | 615,812 | AD | 1(3%) |
9 | MRAP2 | {?Obesity, susceptibility to, BMIQ18} | 615,457 | AD | 1(3%) |
10 | NRP2 | ?Obesity(-;-) | 1(3%) | ||
11 | NTRK2 | Obesity, hvperphagia, and developmental delay | 613,886 | AD | 1(3%) |
12 | PLXNA3 | ?Obesity | 1(3%) | ||
13 | PLXNA4 | ?Obesity | 1(3%) | ||
14 | PPARG | Severe Obesity | 601,665 | AD, AR, Mu | 1(3%) |
15 | SEMA3C | ?Obesity | 1(3%) | ||
16 | SEMA3F | ?Obesity | 1(3%) | ||
17 | SEMA3G | ?Obesity | 1(3%) | ||
18 | SIM1 | ?Obesity | 1(3%) |