Table 4 Diagnostic values of complements in neonatal sepsis
From: Complement levels and their diagnostic utility in neonatal sepsis
Variable | C5a (ng/ml) | MBL (pg/ml) | C5a + MBL |
|---|---|---|---|
AUC (95% CI) | 0.63 (0.51 − 0.75) | 0.75 (0.64 − 0.85) | 0.92 (0.85 − 0.99) |
Sensitivity (95% CI) | 65.9% (50.5−78.4%) | 53.7% (38.7%, 67.9%) | 85.4% (71.6%, 93.1%) |
Specificity (95% CI) | 65.9% (50.5−78.4%) | 90.2% (77.5%, 96.1%) | 97.6% (87.4%, 99.6%) |
PPV (95% CI) | 65.9% (50.5−78.4%) | 84.6% (66.5%, 93.8%) | 97.2% (85.8%, 99.5%) |
NPV (95% CI) | 65.9% (50.5−78.4%) | 66.1% (53.0%, 77.1%) | 87.0% (74.3%, 93.9%) |
Cut-off value | 55.63 | 512.86 | NA |
True positive | 27 | 22 | 35 |
False positive | 14 | 4 | 1 |
False negative | 14 | 19 | 6 |
True negative | 27 | 37 | 40 |