Applicability of multiple quantitative ultrasound liver biomarkers in children and adolescents with severe obesity

Table 4 Associations between ultrasound biomarkers and clinical data and serology tests

Variable	ATI (dB/cm/MHz)			SWE (kPa)			SWD (m/s)/kHz
	Beta (95% CI)	p	R²	Beta (95% CI)	p	R²	Beta (95% CI)	p	R²
BMI	−0.01 (−0.02;−0.00)	0.0007	0.20	0.12 (−0.01;0.25)	0.066	0.07	0.09 (−0.06;0.25)	0.22	0.03
BMI SDS	−0.05 (−0.09;−0.02)	0.0060	0.14	0.71 (0.05;1.37)	0.035	0.09	0.56 (−0.35;1.48)	0.22	0.03
AST (ukat/L)	0.06 (−0.05;0.17)	0.28	0.03	−1.92 (−4.08;0.23)	0.079	0.08	−1.78 (−3.63;0.08)	0.060	0.09
ALT (ukat/L)	0.01 (−0.03;0.05)	0.56	0.01	−0.56 (−1.39;0.28)	0.19	0.04	−0.34 (−1.09;0.40)	0.36	0.02
HbA1c (mmol/mol)	0.00 (−0.01;0.01)	0.60	0.01	−0.20 (−0.36;−0.04)	0.015	0.13	−0.03 (−0.18;0.12)	0.67	0.00
Cholesterol (mmol/L)	0.03 (−0.01;0.07)	0.17	0.04	−0.24 (−1.20;0.73)	0.62	0.01	0.12 (−0.73;0.98)	0.77	0.00
Triglyceride (mmol/L)	0.07 (0.02;0.13)	0.015	0.12	−0.88 (−2.26;0.50)	0.20	0.04	0.23 (−0.99;1.46)	0.70	0.00

The β value for each independent variable indicates the expected change in the dependent variable for a one-unit increase in that independent variable, assuming all other variables in the model are held constant. P probability value, BMI body mass index, SDS standard deviation score, AST aspartate aminotransferase, ALT alanine aminotransferase. CI confidence interval, ATI attenuation imaging, SWE shear wave elastography, SWD shear wave dispersion

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