Fig. 6

Identification of the key COVID-19-related KD hub genes. (a, b) Screening of DEFA4, PGLYRP1, and RETN by LASSO regression analysis.The optimal lambda (lambda.1se) was 0.1563205 based on a 10-fold cross-validation. (c) ROC curves of DEFA4, PGLYRP1, RETN in the training dataset (GSE100154, KD vs. control). (d) ROC curves of DEFA4, PGLYRP1, and RETN in the validation dataset (GSE73461, KD vs. control). AUC: area under the curve