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  1. Patients with thalassemia acquire cellular oxidative damage mainly from the degradation of excessive uncoupled hemoglobin (Hb) chains and iron overload. The oxidative damage of red blood cells (RBCs) and plate...

    Authors: Nutthida Hemprachitchai, Rattanaporn Praneetponkang, Pakawan Wongwerawattanakoon, Chokdee Wongborisuth, Pawarit Innachai, Praguywan Kadegasem, Tanyanee Khlangtan, Thanaporn Sriwantana, Phanphen Phoonlapdacha, Oraporn Dumrongwongsiri, Ampaiwan Chuansumrit, Kovit Pattanapanyasat, Nongnuch Sirachainan, Nathawut Sibmooh, Pornthip Chaichompoo and Duantida Songdej
    Citation: BMC Pediatrics 2025 25:405
    Content type: Research Published on:

  2. Biliary obstruction is a rare complication in patients with hereditary spherocytosis (HS). The clinical course and optimal treatment strategies for HS patients complicated by biliary obstruction remain unclear.

    Authors: Xinjie Huang, Chunhui Peng, Yajun Chen, Dongyang Wu, Wei Chen, Zengmeng Wang and Kai Wang
    Citation: BMC Pediatrics 2025 25:404
    Content type: Research Published on:

  3. Worldwide, neonatal mortality is a major public health burden especially in the developing countries. Several factors are associated with neonatal mortality at the neonatal intensive care unit (NICU). The aim ...

    Authors: Nicholas Aguma, Steven Ekak, Lambert Emetu, Samson Ojok and Peter Akera
    Citation: BMC Pediatrics 2025 25:403
    Content type: Research Published on:

  4. Fathers’ involvement in the care of preterm babies has been associated with good health outcomes for the mother and the baby. However, fathers’ involvement in the Neonatal Unit (NU) in Uganda remains sub-optim...

    Authors: Wycliffe Ssekatawa, Sarah Nakubulwa, Dan Kaye, Joshua Ssebuliba, Charles Loponi Taban, Flaviah Namiiro and Joseph Rujumba
    Citation: BMC Pediatrics 2025 25:402
    Content type: Research Published on:

  5. This scoping review aimed to identify methodological procedures for acquiring and analyzing ultrasound images of the tongue during sucking in full-term infants. The Participants, Concept, and Context strategy ...

    Authors: Anna Fernanda Ferreira de Alves Melo, Roberta Lopes de Castro Martinelli, Rodrigo Alves de Andrade, Ana Paula Alves Figueiredo Lima, Aline Natallia Simões de Almeida, Anna Clara Mota Duque, Daniele Andrade da Cunha and Hilton Justino da Silva
    Citation: BMC Pediatrics 2025 25:401
    Content type: Research Published on:

  6. Infection by the SARS-CoV-2 virus can cause coronavirus disease 2019 (COVID-19) and can also exacerbate the symptoms of Kawasaki disease (KD), an acute vasculitis that mostly affects children. This study used ...

    Authors: Wang Li, Wenjie Zhu, Xiangting Tang, Zhiting Peng, Jiaqi Ye and Shuping Nie
    Citation: BMC Pediatrics 2025 25:400
    Content type: Research Published on:

  7. To improve the nutritional management of premature infants in neonatal intensive care units (NICUs), we developed and implemented a standardized parenteral nutrition (PN) protocol aimed at optimizing early mac...

    Authors: Majid Mahallei, Lida Gorbani, Mohammad Bagher Hoseini, Elnaz Shaseb, Bahareh Mehramuz and Khatereh Rezazadeh
    Citation: BMC Pediatrics 2025 25:399
    Content type: Research Published on:

  8. Only isolated occurrences of neonatal Jka hemolytic disease have been identified, and no cases of Jka hemolytic disease combining fetal and neonatal alloimmune thrombocytopenia (FNAIT) have been reported. The maj...

    Authors: Fangmei Luo, Shangliang Chen, Wenfang Li and Ping Zhou
    Citation: BMC Pediatrics 2025 25:398
    Content type: Case Report Published on:

  9. This investigation was designed to assess the mediating effects of physical exercise and depression on the relationship between family support and Internet addiction (IA) among adolescents in Western China.

    Authors: Yang Liu, Ting Xiao, Wei Zhang, Lei Xu, Yang Wang and Tiancheng Zhang
    Citation: BMC Pediatrics 2025 25:397
    Content type: Research Published on:

  10. As a heterogeneous syndrome, acute respiratory distress syndrome (ARDS) patients with comorbidities are significantly more severely ill. We aim to investigate the clinical characteristics and analyze the risk ...

    Authors: Qingyue Wang, Hongxing Dang, Yueqiang Fu, Chengjun Liu, Jing Li and Feng Xu
    Citation: BMC Pediatrics 2025 25:396
    Content type: Research Published on:

  11. Safe radiological practices are essential in pediatric healthcare because of children’s vulnerability to the chronic impacts of radiation exposure. Having sufficient knowledge is crucial for adopting radiologi...

    Authors: Sondos M. Zorba, Lamis G. Khaled, Abdelrahman Abudyak, Khaled Al-ali, Sari Taha, Jihad M. Hamaida, Mustafa Mahmoud and Sa’ed H. Zyoud
    Citation: BMC Pediatrics 2025 25:395
    Content type: Research Published on:

  12. Although paediatric depression is a recognised problem worldwide, there is limited data on its prevalence in children aged under 5 years, and the role of breastfeeding and medicinal exposure. This study examin...

    Authors: Kanayo Umeh and S Adaji
    Citation: BMC Pediatrics 2025 25:394
    Content type: Research Published on:

  13. Undernourished children are at risk of mortality and infection and tend to present with impaired cognitive and physical development with potentially lower physical fitness and motor skill competence. This meta...

    Authors: Yabsra Melaku Dubale, Tefera Belachew, Beyene Wondafrash, Eugene Rameckers and Evi Verbecque
    Citation: BMC Pediatrics 2025 25:393
    Content type: Research Published on:

  14. Kawasaki disease (KD) is an acute immune-mediated vasculitis primarily affecting coronary arteries, with limited specific diagnostic biomarkers available. Chitinase protein-40 (YKL-40), a glycoprotein secreted...

    Authors: Yalin Liu, Shan Sun, Baolong Yu, Qianyun Wang, Hui Liu, Xianli Shao and Huafeng Zhao
    Citation: BMC Pediatrics 2025 25:392
    Content type: Research Published on:

  16. Obesity is associated with chronic liver disease, which is why improved non-invasive diagnostic assessment of liver affection is desirable. The ultrasound-based biomarkers Attenuation Imaging coefficient (ATI)...

    Authors: Ivan Cetinic, Charlotte de Lange, Kerstin Lagerstrand, Jenny M. Kindblom, Lovisa Sjögren and Hanna Hebelka
    Citation: BMC Pediatrics 2025 25:390
    Content type: Research Published on:

  17. Shone’s complex (SC) comprises multi-level left-sided obstructive cardiac lesions. Limited research has addressed SC in the pediatric age, especially the factors impacting outcomes. Therefore, the current work...

    Authors: Shaimaa Rakha, Marwa Said Ali, Ahmad Abd El Aleem El Derie, Yahya Wahba and Mohammed Magdy Abo Elkheir
    Citation: BMC Pediatrics 2025 25:389
    Content type: Research Published on:

  18. Gastric lipomas are rare benign gastric tumors, with pediatric and adolescent cases being exceptionally uncommon. This report describes a case of a 17-year-old girl with a giant gastric lipoma (> 8 cm) and the...

    Authors: Shaojun Wang, Hong Yang, Na Jiang and Shengbo Jin
    Citation: BMC Pediatrics 2025 25:388
    Content type: Case Report Published on:

  19. Anemia of prematurity is a common concern for extremely low birth weight (ELBW) patients in the neonatal intensive care unit. The hemoglobin threshold at which the benefits of red blood cell transfusion outwei...

    Authors: Amy L. Conrad, Sara B. DeMauro, Haresh Kirpalani, Kristina Ziolkowski, Susan R. Hintz, Betty R. Vohr, Victoria Watson, Tarah T. Colaizy, Edward F. Bell, Jane E. Brumbaugh, Carla M. Bann, Sylvia M. Tan, Jamie E. Newman and Abhik Das
    Citation: BMC Pediatrics 2025 25:387
    Content type: Study Protocol Published on:

  20. Asthma is the most common chronic illness in children and is characterized by airway hyperresponsiveness, increased production of mucus, and significant inflammation. The signal transducer and activator of tra...

    Authors: Haitham Abdulwahab Masood, Arwa Mohammed Othman, Najla Nasr Addin Al-Sonboli, Faiza Abdulnoor Ghlab, Naif Mohammed Al-Haidary and Muhanna M. Al-Shaibani
    Citation: BMC Pediatrics 2025 25:386
    Content type: Research Published on:

  22. Preoperative anxiety is a significant concern for pediatric patients undergoing surgery, often leading to adverse physiological, emotional, and postoperative outcomes. Traditional pharmacological approaches, w...

    Authors: Razie Vakili, Reza Feizi, Yahya Salimi, Mobin Mottahedi and Parisa Rizevandi
    Citation: BMC Pediatrics 2025 25:384
    Content type: Research Published on:

  23. Preterm birth is a leading cause of childhood mortality and developmental disabilities, with persistent socioeconomic disparities in incidence and outcomes. Maternal presence during prolonged neonatal intensiv...

    Authors: Margaret McConnell, Alya Alsager, Plyce Fuchu, Shrivaths Sriprasad, Lindsey Simoncini, Mari-Lynn Drainoni, Erika G. Cordova-Ramos, Michelle-Marie Peña, Laura Madore, Nikita S. Kalluri, Michael Silverstein, Heather Schofield, Martha J. Farah, Günther Fink and Margaret G. Parker
    Citation: BMC Pediatrics 2025 25:383
    Content type: Study Protocol Published on:

  24. Right ventricle (RV) dysfunction because of pulmonary vasculopathy is the most common cause of death in sickle cell disease (SCD). This study aimed to explore the diagnostic accuracy of blood-speckle tracking ...

    Authors: Antoine Fakhry AbdelMassih, Fatima Nabil, Niveen Salama and Ilham Youssry
    Citation: BMC Pediatrics 2025 25:382
    Content type: Research Published on:

  25. The correlation between parental and child physical activity levels has been the subject of significant investigation. Existing research has illuminated this association, particularly emphasising its influence...

    Authors: Fernando Rodríguez-Rodríguez, Carlos Cristi-Montero, Natalia Zurita-Corvalán, Caroline Brand, Jorge Mota, Palma Chillón, Anelise Reis Gaya, Javier Brazo-Sayavera and Nicolás Aguilar-Farias
    Citation: BMC Pediatrics 2025 25:381
    Content type: Study Protocol Published on:

  27. Fatigue is increasingly recognised as a prevalent and debilitating symptom for children and young people (CYP) with long-term conditions (LTCs), significantly affecting their family, social and educational par...

    Authors: Brenda Agyeiwaa Poku, Karl Michael Atkin, John David Grainger, Iyamide Thomas, Rachael Oshinbolu, Abubakar Mohammed, Edith Kyewalyanga and Susan Kirk
    Citation: BMC Pediatrics 2025 25:379
    Content type: Research Published on:

  29. As the increasing survival of preterm infants bearing lower gestational age (GA) and birth weight (BW), new challenges have emerged regarding their management and prognosis. In low- and middle-income countries...

    Authors: Ranran Shi, Xiaoyu Dong, Li Wang, Wenwen Zhang, Simmy Reddy and Yonghui Yu
    Citation: BMC Pediatrics 2025 25:377
    Content type: Research Published on:

  30. Preeclampsia is linked to fetal growth restriction and may have long-term implications for the offspring. Despite its significance, the fundamental mechanisms remain inadequately elucidated. The objective of t...

    Authors: Jing Ding, Yihan Xiao, Jie Fu, Qionghui Huang, Zijun Ma, Chao Zhang, Yan Wang, Guoli Liu, Hongkun Wu and Yifang Yuan
    Citation: BMC Pediatrics 2025 25:376
    Content type: Research Published on:

  32. Blau syndrome (BS) is a rare autoinflammatory disease characterized by a clinical triad of uveitis, dermatitis and arthritis. The aim of our study was to summarize organ involvement, predict disease prognosis ...

    Authors: Xinwei Shi, Jianghong Deng, Junmei Zhang, Xiaozhen Zhao, Yinan Zhao, Li Li, Fengqiao Gao, Weiying Kuang, Jiang Wang, Xiaohua Tan, Chao Li, Shipeng Li and Caifeng Li
    Citation: BMC Pediatrics 2025 25:374
    Content type: Research Published on:

  33. Coarctation of the aorta (CoA) is one of the more prevalent congenital heart diseases (CHD). The conventional treatment approach involves surgical correction of the coarctation. This procedure, however, can be...

    Authors: Huayi Tan, Xinke Zou, Ke Gong, Yifeng Yang, Zhongshi Wu, Jijia Liu and Sijie Wu
    Citation: BMC Pediatrics 2025 25:373
    Content type: Case Report Published on:

  34. Parents of children with a health condition experience high levels of distress which can have long-term impact on the child and parent. Dyadic interventions have the potential to decrease this distress, howeve...

    Authors: Alicia Kilfoy, Isabella Zaffino, Enoch McAtee, Prabdeep Panesar, Kristin Cleverley, Quynh Pham, Charlene H. Chu and Lindsay Jibb
    Citation: BMC Pediatrics 2025 25:372
    Content type: Research Published on:

  35. This study explores ocular manifestations in children with mutations in key tumor suppressor genes (RB1, NF1, NF2, VHL, TSC1/2), which are linked to common pediatric hereditary cancer syndromes. Mutations in t...

    Authors: Aoxiang Wang, Chanyuan Wang, Wen Li, Jing Qiao, Yulin Luo and Yu Tian
    Citation: BMC Pediatrics 2025 25:371
    Content type: Research Published on:

  36. Lower urinary tract symptoms (LUTS) are common in pediatric patients and significantly affect children’s well-being and family-related quality of life. However, no validated Chinese assessment tool for LUTS ex...

    Authors: Yufei Tan, Yanan Xu, Die Liang, Yan Zhang, Wenzhi Cai, Wei Ren and Ling Chen
    Citation: BMC Pediatrics 2025 25:370
    Content type: Research Published on:

  37. Hearing impairment (HI) is a prevalent problem. The majority of cases have HI during the neonatal period, while the still cases have incidence up to adolescents. Hearing amplification is a promising modality t...

    Authors: Dalia Fahim Mohammed Fahim, Sara Ibrahim Sayed, Marwa Ibrahem Abdelrazic and Ibtehal Saad Abuelela
    Citation: BMC Pediatrics 2025 25:369
    Content type: Research Published on:

  38. Claes-Jensen syndrome (CJS) is a rare X-linked intellectual disability caused by mutations in the KDM5C gene, encoding a histone demethylase involved in chromatin remodeling and neurodevelopment. Males with he...

    Authors: Manal M. Shaheen, Ramzi H. Mujahed, Saja E. Abusabha, Iman M. Alwahsh, Areen A. Abufara, Leen J. Junaidi and Haya A. Alkablan
    Citation: BMC Pediatrics 2025 25:368
    Content type: Case Report Published on:

  39. Despite global efforts to promote breastfeeding, the rate of exclusive breastfeeding (EBF) has remained stagnant in recent decades. Identifying factors that influence EBF is crucial. Therefore, this study aime...

    Authors: Arezoo Haseli, Marzieh Bagherinia, Lida Menati, Sareh Farshadfar, Fatemeh Karpasand and Zahra Karimian
    Citation: BMC Pediatrics 2025 25:366
    Content type: Research Published on:

  41. The global rise in pediatric hypertension (HTN) is a significant concern as it serves as a precursor to cardiovascular disease (CVD). To address this, we performed a comparative analysis of two guidelines for ...

    Authors: Jeong Yeon Kim, Sangshin Park and Heeyeon Cho
    Citation: BMC Pediatrics 2025 25:364
    Content type: Research Published on:

  42. Perforated peptic ulcers (PPU) represent a significant complication of peptic ulcers, associated with high mortality. As no systematic review of the literature on PPU in children currently exists, this study a...

    Authors: Stipe Vidović, Sara Borović, Marko Bašković, Joško Markić and Zenon Pogorelić
    Citation: BMC Pediatrics 2025 25:363
    Content type: Research Published on:

  43. To investigate the clinical and genetic characteristics of classic congenital adrenal hyperplasia (CAH) patients. To determine whether gonadotropin-releasing hormone analogs (GnRHa) + recombinant human growth ...

    Authors: Xiaoxiao Liu, Fei Liu, Yingyi Qi, Xinyi Han, Shifeng Ma and Rongxiu Zheng
    Citation: BMC Pediatrics 2025 25:362
    Content type: Research Published on:

  44. Predicting fluid responsiveness is challenging in infants. It is however crucial to avoid unnecessary volume expansion, which can lead to fluid overload. We tested the hypothesis that the stroke volume changes...

    Authors: Julien Gotchac, Anouk Navion, Yaniss Belaroussi, Roman Klifa, Pascal Amedro, Julie Guichoux and Olivier Brissaud
    Citation: BMC Pediatrics 2025 25:361
    Content type: Research Published on:

  45. To investigate the efficacy of external fixation in treating unstable pelvic fractures in children and identify risk factors for poor prognosis.

    Authors: Hanwen Zhang, Ronghao Zhao, Danjiang Zhu, Wei Feng, Baojian Song and Qiang Wang
    Citation: BMC Pediatrics 2025 25:360
    Content type: Research Published on:

  47. This study aimed to investigate the genetic etiology and clinical features of non-syndromic pediatric obesity in a large Chinese cohort, providing insights into the genetic profile and its correlation with cli...

    Authors: Huang Hui, Yang Yu, Liang Yiwei, Yang Li, Xie Liling and Zhang Dongguang
    Citation: BMC Pediatrics 2025 25:358
    Content type: Research Published on:

  48. Polymelia, or accessory limb, is a rare congenital abnormality with unknown etiology. Here we report the case of an infant with an accessory limb, review the diagnostic and therapeutic consideration of such ca...

    Authors: Mohammad Mahdi Ebrahiminasab, Taghi Baghdadi, Pouya Tabatabaei Irani and Soroush Baghdadi
    Citation: BMC Pediatrics 2025 25:357
    Content type: Case Report Published on:

  49. There is a lack of consensus among pediatric surgeons regarding the optimal management of a macroscopically normal appendix encountered during laparoscopy in children with suspected acute appendicitis. We here...

    Authors: Wael Abosena, Mohamed Ahmed Elghazeery, Hisham Almohamady Almetaher and Ahmed Mostafa Aboelyazeed
    Citation: BMC Pediatrics 2025 25:356
    Content type: Research Published on:

  50. Childhood cancer and its therapy, especially that involving potentially cardiotoxic cancer treatment, can structurally affect muscle strength and heart function, and therefore may result in lowered physical ac...

    Authors: Julia Haponiuk-Skwarlińska, Jakub S. Gąsior, Katarzyna Albrecht, Paweł Łaguna and Bożena Werner
    Citation: BMC Pediatrics 2025 25:355
    Content type: Study Protocol Published on:
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BMC Pediatrics

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