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Cardiac tumors in children are rare and usually have no obvious clinical symptoms. However, a small number of children may experience serious conditions such as arrhythmia, heart obstruction, and even death. W...
During the preschool years, children experience rapid development of inhibitory control (IC). This period is also crucial to foster the establishment of the foundations of physical fitness (PF) and motor compe...
Neonatal sepsis is a significant cause of morbidity and mortality in low- income countries. Neonatal sepsis is classified as early-onset neonatal sepsis (EONS) and late-onset neonatal sepsis (LONS). Etiologies...
Here we describe the case of an infant incidentally diagnosed with congenital KMT2A-rearranged (KMT2A-r) B-cell ALL on Day of Life 4. He received the first dose of intrathecal methotrexate on DOL 5, and induct...
Perinatal asphyxia is one of the leading causes of neonatal morbidity and mortality in the world. While there is much published data on the epidemiology of perinatal asphyxia in African countries, there is a l...
Poor growth is one of the major obstacles to human development, affecting millions of children under the age of 5 years, particularly those living in low- and middle-income countries (LMICs). The objective of ...
Premature ventricular complexes (PVCs) are generally benign in healthy children, but in some cases, a persistent high PVC burden may be observed, potentially related to ventricular tachycardia or left ventricu...
This meta-analysis investigates the efficacy of infliximab in reducing vascular damage, suppressing inflammation, and promoting mucosal healing in patients with immunoglobulin-resistant Kawasaki Disease (KD). ...
Familial exudative vitreoretinopathy (FEVR) is an inherited disorder of retinal vascularization insufficiency caused primarily by genetic mutations. So far, FEVR has been less reported in the Chinese populatio...
Effective management of neonatal pain and stress is crucial, with non-pharmacological approaches like maternal odor showing promise. However, mixed evidence exists on its efficacy. This study aims to comprehen...
Obesity among the young is an emerging health problem with many metabolic changes including liver damage. Our objective was to investigate the association of fatty liver with serum uric acid (UA) and gamma-glu...
Forward head posture is a common postural issue across all age groups, often linked to the overuse of electronic devices such as computers, smartphones, and tablets, leading to poor posture in children. Allerg...
Randomized controlled trial (RCT) data are analyzed by two challengeable adjusted and non-adjusted approaches. Performing appropriate adjusted analysis leads to a more interpretable and efficient estimation of...
Thrombotic microangiopathy (TMA) is a serious complication that can occur in patients with systemic lupus erythematosus (SLE), and TMA adversely affects prognosis and increases mortality. The treatment of TMA ...
Birth asphyxia is the second leading cause of neonatal mortality worldwide, including in Ethiopia, and remains a significant public health concern. Despite the availability of national data on neonatal mortali...
Autoimmune polyendocrinopathy candidiasis ectodermal dystrophy (APECED), also known as autoimmune polyendocrine syndrome type I (APS-I) is an inborn error of immunity (IEI) with an immune dysregulation phenoty...
Intraventricular hemorrhage (IVH) is one of the critical complications of prematurity with severe forms, associated with irreversible brain damage. We hypothesized that infants born in South Africa may have di...
Multisystem inflammatory syndrome in children (MIS-C), a complication of COVID-19, is frequently associated with cardiac involvement. Although most affected children recover, the extent and duration of myocard...
Preterm delivery is the leading cause of neonatal morbidity and mortality. This study performed a systematic review and meta-analysis to compare the efficacy of transdermal nitroglycerin and oral nifedipine in...
A road traffic accident is a collision between vehicles, between pedestrians and vehicles, between vehicles and animals, or between fixed obstacles and vehicles that leads to fatal human injury and premature d...
Neonatal activity is an important physiological parameter in the neonatal intensive care unit (NICU). The degree of neonatal activity is associated with under and over-sedation and may also indicate the onset ...
Participation in sports is the main manifestation/subdomain of physical exercise in adolescents and affects cardiovascular health in different ways.
Fetal lower urinary tract obstruction (LUTO) is a rare congenital disease associated with high morbidity and mortality due to pulmonary hypoplasia and renal insufficiency. Fetal management includes early vesic...
Inborn babies in many Ghana facilities who need any monitoring or therapy above Essential Newborn Care (ENC) are often separated from postnatal ward dyadic care and sent to Neonatal Units (NUs) due to personne...
The signaling pathway of C-type natriuretic peptide (CNP) and its receptor (natriuretic peptide receptor 2, NPR2) is implicated in the process of endochondral ossification, which is crucial for the linear grow...
Childhood stunting is a significant public health challenge in Tanzania, affecting over one-third of the children. It has long-term consequences for growth, development, and the overall health status. The high...
Pediatric hydrocele is a congenital pathology commonly diagnosed in newborns. Also, untreated pediatric hydrocele can induce adverse permanent consequences in adulthood. This study aimed to investigate the glo...
Dihydrolipoamide dehydrogenase deficiency (DLDD) (OMIM# 246,900) is an extremely rare inherited metabolic disorder causing neurological and/or liver impairment. The clinical manifestations are mostly character...
The preoperative diagnosis of Hirschsprung disease (HD) requires a rectal mucosal biopsy and acetylcholinesterase (AchE) staining. However, the optimal timing for performing these procedures remains unclear. I...
Parental health literacy plays a critical role in children’s health and development. This study was conducted to reveal the relationship between parents’ health literacy level and anthropometric measurements a...
Diet is likely related to sleep quality and mental health, especially during lactation. In this study, we aimed to investigate whether adherence to the healthy Mediterranean diet (MD) was correlated with sleep...
The use of lipid emulsion in TPN for preterm infants can affect clinical outcomes.
Physical education exercise has a positive effect on adolescents' physical fitness and working memory function, but it has not been found in studies on Uyghur adolescents, an ethnic minority in western China. ...
Camphor (CMP) is widely used for cultural and medicinal purposes in regions like the Middle East, India, Nigeria, and Latin America. Despite its traditional uses, CMP presents serious toxic risks, particularly...
Sacroiliac joint (SIJ) remodeling in pediatric patients following trauma is a rare phenomenon with limited documentation in medical literature. This case report presents a unique instance of post-traumatic SIJ...
Lipid metabolism plays an important role in fetal growth and development, but its role in lung maturation is currently unknown. We investigated the relationship between early serum lipid levels and clinical ch...
Early-onset sepsis (EOS) remains a significant cause of morbidity and mortality in neonates worldwide, particularly in low-income countries. Identification of causative bacterial pathogens and assessment of th...
Antibiotic-induced disruption of the gut microbiome in the first 1000 days of life is linked to an increased risk of the development of immunological, metabolic, and neurobehavioral childhood-onset conditions....
To assess the pooled prevalence and predictors of intraventricular hemorrhage (IVH) among preterm neonates born between 28 and 34 weeks of gestational age in Africa.
Phototherapy is a common treatment for neonatal hyperbilirubinemia, however it generates reactive oxygen species and induces apoptosis, potentially influencing blood cells. Assessing changes in hematological p...
Upper extremity deep venous thrombosis (UEDVT) is a disease caused by angiectopia and hypercoagulation,　which result in the superficial vein to become dilatated by the development of collateral circulation. Th...
The original article was published in BMC Pediatrics 2025 25:35
Cerebral Palsy (CP) is an umbrella term for a group of permanent postural and movement conditions caused by non-progressive damage to the developing brain. Infants not identified with risk factors for CP aroun...
To validate the effectiveness of the application of a transition programme for adolescents with chronic kidney disease based on the Integrated Theory of Health Behavior Change.
This study aimed to evaluate the clinical effect of transcutaneous pelvic floor magnetic stimulation combined with urination training in the treatment of overactive bladder (OAB) in children.
Dental plaque is a major contributor to oral diseases, particularly in children, but its impact can be significantly mitigated through targeted oral health education. This study aimed to evaluate the effective...
This retrospective study was designed to identify the incidence, outcome and analyze risk factors of perioperative pulmonary complications in children with mediastinal mass so that to achieve the Enhanced Reco...
Methylmalonic acidaemia (MMA) is a genetic metabolic disorder caused by congenital defects that may result in multisystem damage. However, MMA complicated with acute myeloid leukemia (AML) is very rare.
Sleep disorders are common in high school students. Despite the growing global attention to adolescent sleep issues, limited research has focused on the knowledge, attitude, and practice (KAP) of high school s...
The prescribing of antidepressants and antipsychotics to children has increased worldwide, but little is known about how changes in drug funding policy influence the practice. In 2018, Ontario introduced a uni...
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